The question I’m asked most about polynucleotides is a fair one: when will I see something? The honest answer is that this is a gradual treatment. It asks for a little patience, and it rewards it.
The timeline, in plain terms
- Gradually, from your first session: your skin starts to improve.
- From about 4 weeks: this is when most people start to see a visible difference.
- Over 3 to 6 months: the full effect on texture, elasticity and tone builds.
- Up to 9 months: how long results typically last, depending on your age, your lifestyle and your skin.
Why it takes time
Polynucleotides work with your skin, and skin renews itself slowly. New skin cells take about four weeks to form in the lower layers, then come up through the skin over the following months. So what you see in the first few weeks is only the beginning.
That’s also why I recommend a course. One session starts the process. Three sessions, 4 weeks apart, give your skin the chance to build on each one.
How many sessions you’ll need
For most people it’s a course of 3 sessions, spaced 4 weeks apart. Very tired or sun-damaged skin sometimes benefits from a fourth, and I’ll tell you at your consultation if I think that’s you.
How to make results last
After your course, 1 to 2 maintenance sessions a year help keep your skin where you want it. How long your results last depends on your skin and how you look after it day to day. I’ll always tell you honestly when I think you’re due, and when you’re not.
Planning around an event
Because polynucleotides work gradually, they aren’t a treatment to fit in the week before something important. If you have a wedding, a holiday or a big birthday in mind, start well in advance, so your skin has had time to respond. Come and see me early and we can plan it properly.
The neck and the under-eyes
The same timeline applies wherever you’re treated. On the neck in particular, results build gradually over the months after your course, so the skin looks a little tighter and firmer over time. Necks are often forgotten about, and they take patience.
For the under-eyes, I’ve written a separate guide to what polynucleotides can and can’t do under the eyes.
Real clients of mine. Every face is different, so results vary from person to person. All treatments carry risks. Consultation first.
Your questions
Will I see anything after the first session?
Some people notice their skin looks a little fresher within a couple of weeks. The real change comes from the course, and it carries on building after your last session.
How often should I have maintenance?
Usually once or twice a year, so every 6 to 12 months. It depends on your skin, and I’ll guide you.
What does a course cost?
Polynucleotides are £300 a session, or £660 for a course of three, which saves £240. Your £30 consultation comes off your treatment.
Where to find me
I treat every client myself at 260 Pentonville Road in King’s Cross, a short walk from King’s Cross St Pancras and walkable from Angel and Islington. If you’d like to know whether polynucleotides are right for your skin, book a consultation or read more about polynucleotides at my clinic.




